VDB admits doping...?

According to sportenkort.dk VDB has admitted to doping.

There is no reference to where the news came from, and I haven't found it on
any other media. I guess it was to be expected that his dog didn't do it
(!), but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

Musseuws secret codes with his vet just makes the story even more crazy.

Is there any confirmation of the above mentioned?

HB

"HB" marrone-ALPHA_A-sol.dk wrote in message
k...
According to sportenkort.dk VDB has admitted to doping.

There is no reference to where the news came from, and I haven't found it
on
any other media. I guess it was to be expected that his dog didn't do it
(!), but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

Musseuws secret codes with his vet just makes the story even more crazy.

Is there any confirmation of the above mentioned?


It was a report in the Flemish newspaper "Het laatste niews". It's unusual,
true, but it's probably a strategic retreat to a second line of defense.
Since the police has found eleven illicit products in his home, such as
growth hormones, testosteron, clembuterol, morphine, amphetamine, diuretic,
etc., it's probably no use anymore to continue denying.

Benjo Maso

am I in a time warp here or is this recent news?


"benjo maso" wrote in message
...

"HB" marrone-ALPHA_A-sol.dk wrote in message
k...
According to sportenkort.dk VDB has admitted to doping.

There is no reference to where the news came from, and I haven't found
it
on
any other media. I guess it was to be expected that his dog didn't do it
(!), but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

Musseuws secret codes with his vet just makes the story even more crazy.

Is there any confirmation of the above mentioned?


It was a report in the Flemish newspaper "Het laatste niews". It's
unusual,
true, but it's probably a strategic retreat to a second line of defense.
Since the police has found eleven illicit products in his home, such as
growth hormones, testosteron, clembuterol, morphine, amphetamine,
diuretic,
etc., it's probably no use anymore to continue denying.

Benjo Maso

"JTN" wrote in message ...
am I in a time warp here or is this recent news?

It's news because previously it was only his dog that was doping.

"Kevin Delaney" wrote in message
om...
"JTN" wrote in message
...
am I in a time warp here or is this recent news?

It's news because previously it was only his dog that was doping.




Dumbass -


That dog story still makes me laugh.


If the authorities come in and find my stash of Pot Belge, I'll be sure to
blame it on my parrot, but it doesn't seem like that excuse will work in the
States.

"Kurgan Gringioni" wrote in
message t...

"Kevin Delaney" wrote in message
om...
"JTN" wrote in message
...
am I in a time warp here or is this recent news?

It's news because previously it was only his dog that was doping.




Dumbass -


That dog story still makes me laugh.


If the authorities come in and find my stash of Pot Belge, I'll be sure to
blame it on my parrot, but it doesn't seem like that excuse will work in
the
States.

I see the humor, but it is actually an excellent defense. The drugs he
claims were for the dog are very commonly prescribed for dogs. Still, it
looks bad since the connection with the corrupt veterinarian came to light
recently (and now this).

benjo maso wrote:

"HB" marrone-ALPHA_A-sol.dk wrote in message
k...

According to sportenkort.dk VDB has admitted to doping.

There is no reference to where the news came from, and I haven't found it

on

any other media. I guess it was to be expected that his dog didn't do it
(!), but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

Musseuws secret codes with his vet just makes the story even more crazy.

Is there any confirmation of the above mentioned?



It was a report in the Flemish newspaper "Het laatste niews". It's unusual,
true, but it's probably a strategic retreat to a second line of defense.
Since the police has found eleven illicit products in his home, such as
growth hormones, testosteron, clembuterol, morphine, amphetamine, diuretic,
etc., it's probably no use anymore to continue denying.

Benjo Maso




Didn't sound like he's doing all the well "clean", either, but I'm
amazed at the naivity of such a defense...

"Well, everyone else is doing it!"

That line never got me out of trouble as a kid, can't figure out how
someone his age could believe that's going to sway a judge.

Is there any confirmation of the above mentioned?

Just checked Belgium teletekst and they also mention this. They qoute from Belgium newspaper Het Laatste Nieuws so nothing official.
Statements are about the same: "VDB confessed doping use to investigators", "he told them top-sport is impossible without doping".
They also mention that VDB had all kind of stuff laying around to bypass/fool doping checks. It seems that drips, needles and
syringes were found scattered in his home. They also mention a list with all substances found at 27 februari 2002: growth hormones,
testosteron, clenbuterol, aranesp (latest EPO), morfine, amfetamines, moisture eliminators and four other non described products.
The investigations also seem to show that containers were opened.


"HB" marrone-ALPHA_A-sol.dk wrote in message k...
According to sportenkort.dk VDB has admitted to doping.

There is no reference to where the news came from, and I haven't found it on
any other media. I guess it was to be expected that his dog didn't do it
(!), but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

Musseuws secret codes with his vet just makes the story even more crazy.

Is there any confirmation of the above mentioned?

HB

, but a rider like VDB saying that there's no way of competing at top
level without doping is quite unusual.

it's the only way. only someone on a fools errand would try to deny
it.

Kyle Legate wrote:
Maybe by the _next_ Athens Olympics, but not these ones. The technology
is not there yet. What you quoted was an ill-informed piece of fluff.



I have a feeling Kurgmeister is right.

Tetracycline induceable systems for regulated expression are showing
promise. Adeno associated vectors can be made to integrate into the
genome, or to just transiently infect:




DNA Cell Biol. 2002 Dec;21(12):895-913. Related Articles, Links


Adenovirus and adeno-associated virus vectors.

Lai CM, Lai YK, Rakoczy PE.

Centre for Ophthalmology and Visual Science, University of Western
Australia, Nedlands, Western Australia.

Recombinant adenovirus (rAd) and recombinant adeno-associated virus
(rAAV) are among the most extensively used vectors in gene therapy
studies to date. These two vectors share some similar features such as a
broad host range and ability to infect both proliferating and quiescent
cells. However, they also possess their own unique set of properties
that render them particularly attractive for gene therapy applications.
rAd vectors can accommodate larger inserts, mediate transient but high
levels of protein expression, and can be easily produced at high titers.
Development of gutted rAd vectors has further increased the cloning
capacity of these vectors. The gaining popularity of rAAV use in gene
therapy can be attributed to its lack of pathogenicity and added safety
due to its replication defectiveness, and its ability to mediate
long-term expression in a variety of tissues. Site-specific integration,
as occurs with wild-type AAV, will be a unique and valuable feature if
incorporated into rAAV vectors, further improving their safety. This
paper describes these properties of rAd and rAAV vectors, and discusses
further development and vector improvements that continue to extend the
utility of these vectors, such as cell retargeting by capsid
modification, differential transduction by use of serotypes, and
extension of the cloning capacity of rAAV vectors by dual vector
heterodimerization.


Hum Gene Ther. 2003 Sep 1;14(13):1265-77.

Tight positive regulation of transgene expression by a single adenovirus
vector containing the rtTA and tTS expression cassettes in separate
genome regions.

Mizuguchi H, Xu ZL, Sakurai F, Mayumi T, Hayakawa T.

Division of Cellular and Gene Therapy Products, National Institute of
Health Sciences, Tokyo 158-8501, Japan.

We previously developed single adenovirus (Ad) vectors that contained
the components for a tetracycline-regulatable gene-expression system
in the E1 and E3 deletion regions, and showed that the Ad vectors
containing the tet-on system exhibit a much inferior regulation of
transgene expression than those containing the tet-off system. In many
cases, the tet-on system may be preferable because of its positive
regulation of transgene expression. To this end, in the present study,
by introducing the latest generation reverse tetracycline-responsive
transcriptional activator (rtTA2s-M2 or rtTA2s-S2) and the
tetracycline-controlled transcriptional silencer (tTS) into the
original tet-on system, we constructed various modified Ad-mediated
tet-on systems. Among them, the novel single Ad vector, which
contained three heterologous gene-expression cassettes of the gene of
interest, rtTA2s-S2, and tTS in the E1 deletion region, the E3
deletion region, and the region between E4 and 3'ITR, respectively,
displayed vastly improved doxycycline-inducible gene expression in
terms of low basal expression, high induced expression, and high
responsiveness to doxycycline both in vitro and in vivo. These results
also suggest that the low responsiveness to doxycycline may explain
why the original tet-on system in the context of the Ad vector is not
effective in vivo. This is the first report describing the cloning of
three heterologous gene-expression cassettes into three separate
regions of the E1/E3-deleted Ad genome. This improved Ad-mediated
tet-on system might be useful for gene therapy and greatly facilitate
the analyses of gene function.

PMID: 12952598 [PubMed - in process]



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