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#171
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On Sep 18, 10:37*pm, "Edward Dolan" wrote:
"JimmyMac" wrote in message ... On Sep 15, 6:00 pm, "Edward Dolan" wrote: [...] I remember after my first PSA test, which was high, I was later examined by an old school doctor at the VA who relied strictly on the digital exam. He assured me I did not have prostate cancer, but still I worried about that high PSA. So I repeated it until there was no mistake. My PSA was rising steadily and fast. A biopsy confirmed that I had prostate cancer. The PSA test is not definitive. But a biopsy is. PSA is a biomarker that is flawed, but it is the best that we have until promising horizon methods become available. *In the interim, free PSA, PSA velocity, and PSA density tests are helpful. *Just the same, PSA screening remains controversial because it is has not been definitively established if the PSA test actually saves lives. Moreover, it is not clear that the benefits of PSA screening outweigh the risks of follow-up diagnostic tests and cancer treatments. For instance, the PSA test may detect small cancers that would never become life threatening. Almost everyone I know my age has a slightly elevated PSA, but they are all on the watchful waiting regime. On the other hand, if the PSA is fairly high to begin with and is rising rapidly, your only recourse is a biopsy, a not particularly dangerous procedure. I recently read that 20% of 20 year old already have some prostate cancer cells. I was shocked and dismayed. As concern a DRE, one can have prostate cancer without palpable tumors, so just like the PSA , a DRE is not entirely a sole reliable indicator. I have just spent the past day at the ER for a stomach ailment. They put me through every standard routine test to make sure I did not have something that was going to kill me. In the end, "you probably got a bug that will pass." Was that information worth over $1000? Until today, I thought I might have stomach cancer. Often the price of reassurance is steep, but whether worth it or not is a judgment call that only the individual with the malady and pocketbook can make. The trouble is that you never know for sure one way or another. Your symptoms will normally either get better to get worse. But if you wait on that outcome, you can easily expire from whatever is ailing you - most especially if you are old like I am. Yep, its a crap shoot and a crap shoot is a gamble and what's at stake is near an dear to you on a very personal level. Emergency Rooms are truly remarkable places. If you fear for your life, that is where you want to be. A trauma center is better yet since trauma centers generally have a greater depth of experience adn are often associated with teaching institutions that are on top of the cutting edged of medical technology and treatment. Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
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#172
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"JimmyMac" wrote in message
... On Sep 18, 10:37 pm, "Edward Dolan" wrote: [...] Emergency Rooms are truly remarkable places. If you fear for your life, that is where you want to be. A trauma center is better yet since trauma centers generally have a greater depth of experience adn are often associated with teaching institutions that are on top of the cutting edged of medical technology and treatment. Smaller towns will not have trauma centers. It is either the ER or nothing. I am struck by the excellence of the doctors manning the ERs. That seems to be their specialty as they remain on that particular job for years and keep very odd hours besides. -- Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
#173
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On Sep 21, 10:29*pm, "Edward Dolan" wrote:
"JimmyMac" wrote in message ... On Sep 18, 10:37 pm, "Edward Dolan" wrote: [...] Emergency Rooms are truly remarkable places. If you fear for your life, that is where you want to be. A trauma center is better yet since trauma centers generally have a greater depth of experience adn are often associated with teaching institutions that are on top of the cutting edged of medical technology and treatment. Smaller towns will not have trauma centers. It is either the ER or nothing. I am struck by the excellence of the doctors manning the ERs. That seems to be their specialty as they remain on that particular job for years and keep very odd hours besides. Understood. That is merely a choice limiting decision based primarily upon one's geophysical place of residence/. On another note, revisiting a previous topic of conversation, regarding detection of prostate cancer via DRE and/or PSA, one study found that in men 40-50 years of age, tumors detected at time of autopsy were 40% whereas tumors detected clinically (read DRE/PSA) in the same age group of the living was mere 1"% ... not very encouraging now is it? Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
#174
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"JimmyMac" wrote in message
... On Sep 21, 10:29 pm, "Edward Dolan" wrote: [...] Smaller towns will not have trauma centers. It is either the ER or nothing. I am struck by the excellence of the doctors manning the ERs. That seems to be their specialty as they remain on that particular job for years and keep very odd hours besides. Understood. That is merely a choice limiting decision based primarily upon one's geophysical place of residence/. On another note, revisiting a previous topic of conversation, regarding detection of prostate cancer via DRE and/or PSA, one study found that in men 40-50 years of age, tumors detected at time of autopsy were 40% whereas tumors detected clinically (read DRE/PSA) in the same age group of the living was mere 1"% ... not very encouraging now is it? The doctors at the VA insisted on a biopsy because of my high PSA test. It was an in-office procedure and is definitive. But alas, most men never get to the biopsy point until too late because the PSA test is usually all over the map. The DRE is pretty worthless. You have to catch prostate cancer before the physical tumor stage, i.e., before it has spread. I read every day about men, many not so old, who are still dying of prostate cancer. The trick is to catch it early before it has spread. Every man over the age of 50 should be getting the PSA test every year even though it isn't totally reliable. Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
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On Sep 23, 8:35*pm, "Edward Dolan" wrote:
"JimmyMac" wrote in message ... On Sep 21, 10:29 pm, "Edward Dolan" wrote: [...] Smaller towns will not have trauma centers. It is either the ER or nothing. I am struck by the excellence of the doctors manning the ERs. That seems to be their specialty as they remain on that particular job for years and keep very odd hours besides. Understood. *That is merely a choice limiting decision based primarily upon one's geophysical place of residence. On another note, revisiting a previous topic of conversation, regarding detection of prostate cancer via DRE and/or PSA, one study found that in men 40-50 years of age, tumors detected at time of autopsy were 40% whereas tumors detected clinically (read DRE/PSA) in the same age group of the living was mere 1"% ... not very encouraging now is it? The doctors at the VA insisted on a biopsy because of my high PSA test. It was an in-office procedure and is definitive. A prostate biopsy is definitive, but the experience of the doctor on the other end of the telescope is crucial. Like any profession, there are some that are better than others at their craft. The one disturbing risk of a prostate biopsy is needle track seeding which can spreed the disease. But alas, most men never get to the biopsy point until too late because the PSA test is usually all over the map. The DRE is pretty worthless. You have to catch prostate cancer before the physical tumor stage, i.e., before it has spread. Not quite true, Yes the DRE is not definitive nor is a PSA test, but until better tools become available (some are almost there).that is what is commonly employed. ON the other hadn you don't have to catch prostate cancer before the tumor stage and often enough won't. As long as the tumor is discovered when still organ confined, a prostatectomy or radiation can, in most instances, be a life saver. Once the disease has spread to seminal vesicles, lymph nudes or has metastasized to bone, prognosis is far less promising. I read every day about men, many not so old, who are still dying of prostate cancer. The trick is to catch it early before it has spread. Every man over the age of 50 should be getting the PSA test every year even though it isn't totally reliable. Since prostate cancer is now more commonly being discovered in younger men, the current wisdom is to get a PSA every year beginning at age 40. Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
#176
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"JimmyMac" wrote in message
... On Sep 23, 8:35 pm, "Edward Dolan" wrote: [...] But alas, most men never get to the biopsy point until too late because the PSA test is usually all over the map. The DRE is pretty worthless. You have to catch prostate cancer before the physical tumor stage, i.e., before it has spread. Not quite true, Yes the DRE is not definitive nor is a PSA test, but until better tools become available (some are almost there).that is what is commonly employed. ON the other hadn you don't have to catch prostate cancer before the tumor stage and often enough won't. As long as the tumor is discovered when still organ confined, a prostatectomy or radiation can, in most instances, be a life saver. Once the disease has spread to seminal vesicles, lymph nudes or has metastasized to bone, prognosis is far less promising. There has been a recent large study about which treatment is the least disruptive to a normal life. Prostatectomy is the worst, followed by radiation, followed by seeding, the least disruptive. How is your anti-hormonal treatment going? I just had 1 shot in the belly prior to radiation and seeding and had a non-ending series of hot flashes for 4 months as a result. I don't know if I could live with those shots. I read every day about men, many not so old, who are still dying of prostate cancer. The trick is to catch it early before it has spread. Every man over the age of 50 should be getting the PSA test every year even though it isn't totally reliable. Since prostate cancer is now more commonly being discovered in younger men, the current wisdom is to get a PSA every year beginning at age 40. Yes, better safe than sorry! -- Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
#177
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On Sep 27, 11:48*am, "Edward Dolan" wrote:
"JimmyMac" wrote in message ... On Sep 23, 8:35 pm, "Edward Dolan" wrote: [...] But alas, most men never get to the biopsy point until too late because the PSA test is usually all over the map. The DRE is pretty worthless. You have to catch prostate cancer before the physical tumor stage, i.e., before it has spread. Not quite true, *Yes the DRE is not definitive nor is a PSA test, but until better tools become available (some are almost there).that is what is commonly employed. *ON the other hadn you don't have to catch prostate cancer before the tumor stage and often enough won't. *As long as the tumor is discovered when still organ confined, a prostatectomy or radiation can, in most instances, be a life saver. Once the disease has spread to seminal vesicles, lymph nudes or has metastasized to bone, prognosis is far less promising. There has been a recent large study about which treatment is the least disruptive to a normal life. Prostatectomy is the worst, followed by radiation, followed by seeding, the least disruptive. How is your anti-hormonal treatment going? I just had 1 shot in the belly prior to radiation and seeding and had a non-ending series of hot flashes for 4 months as a result. I don't know if I could live with those shots. Hot flashes are the least of my worries and I don't suffer too badly from them. I am more concerned about the long term effects of hormonal therapy. There is a downside to androgen deprivation therapy (ADT). Adverse acute menopausal side effects include hot flashes, abdominal fat deposit, breast pain and/or enlargement, reduction in the size of testes and penis, loss of lean muscle mass, emotional changes, anxiety, depression, weight gain, fatigue, impotence, and loss of libido. More serious side effects include anemia, loss of bone mass (osteopenia/osteoporosis), Type-II diabetes, cardiovascular disease, elevated cholesterol and triglycerides, memory impairment, cognitive decline, adverse effects on the liver, increased risk of skeletal related event (pathological fracture), colorectal cancer, and excess serum cortisol. Some anti-aging experts refer to cortisol as the "death hormone" because of the multiple degenerative effects that it produces including immune dysfunction, brain cell injury, and arterial wall damage. Regardless, I had only two alternatives. I could allow the disease to rapidly progress unabated, or I could opt for ADT to survive longer. I chose the latter. I read every day about men, many not so old, who are still dying of prostate cancer. The trick is to catch it early before it has spread. Every man over the age of 50 should be getting the PSA test every year even though it isn't totally reliable. Since prostate cancer is now more commonly being discovered in younger men, the current wisdom is to get a PSA every year beginning at age 40. Yes, better safe than sorry! -- Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
#178
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"JimmyMac" wrote in message
... On Sep 27, 11:48 am, "Edward Dolan" wrote: [...] There has been a recent large study about which treatment is the least disruptive to a normal life. Prostatectomy is the worst, followed by radiation, followed by seeding, the least disruptive. How is your anti-hormonal treatment going? I just had 1 shot in the belly prior to radiation and seeding and had a non-ending series of hot flashes for 4 months as a result. I don't know if I could live with those shots. Hot flashes are the least of my worries and I don't suffer too badly from them. I am more concerned about the long term effects of hormonal therapy. There is a downside to androgen deprivation therapy (ADT). Adverse acute menopausal side effects include hot flashes, abdominal fat deposit, breast pain and/or enlargement, reduction in the size of testes and penis, loss of lean muscle mass, emotional changes, anxiety, depression, weight gain, fatigue, impotence, and loss of libido. The loss of libido I also consider a serious matter in addition to the hot flashes. It why I will never neuter any of my cats. It is best to function as a normal creature for as long as possible. Mankind is not smart enough to mess with mother nature. What is remarkable to me in light of all the adverse side effects that you list is that many guys who were being treated and supposedly cured of their prostate cancer at the VA in Seattle were going to continue the anti-hormone treatments anyway. That is how much they feared prostate cancer. I thought that was crazy and never even considered such a course. More serious side effects include anemia, loss of bone mass (osteopenia/osteoporosis), Type-II diabetes, cardiovascular disease, elevated cholesterol and triglycerides, memory impairment, cognitive decline, adverse effects on the liver, increased risk of skeletal related event (pathological fracture), colorectal cancer, and excess serum cortisol. Some anti-aging experts refer to cortisol as the "death hormone" because of the multiple degenerative effects that it produces including immune dysfunction, brain cell injury, and arterial wall damage. Regardless, I had only two alternatives. I could allow the disease to rapidly progress unabated, or I could opt for ADT to survive longer. I chose the latter. You chose the only treatment you could have chosen. I would not worry too much about those "serious side effects". I had a friend here in Worthington who had the same diagnosis as you and the same treatment and he lived for well over 10 years and never had any side effects except the ones I have already mentioned (he died of kidney failure at age 83). Just be thankful that the hot flashes do not bother you much and that you do not mind the loss of libido. -- Ed Dolan the Great - Minnesota aka Saint Edward the Great - Order of the Perpetual Sorrows - Minnesota |
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