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Surprised you people aren't talking about this
Science, Vol 305, Issue 5687, 1112-1113 , 20 August 2004
Enhanced: Lactic Acid--The Latest Performance-Enhancing Drug Runners routinely blame their weak and aching muscles on the accumulation of lactic acid. But not so fast, say Allen and Westerblad in their Perspective. They discuss a study (Pedersen et al.) revealing that lactic acid accumulation can, in fact, be beneficial by helping to restore force to weakened muscles. By altering the activity of chloride ion channels, lactic acid may actually boost the generation of action potentials and, hence, muscle activity even as the muscles begin to fatigue............ Intracellular Acidosis Enhances the Excitability of Working Muscle Thomas H. Pedersen,1 Ole B. Nielsen,1 Graham D. Lamb,2 D. George Stephenson2* Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working muscles. Here, we show that this process may be mediated by decreased chloride permeability, which enables action potentials to still be propagated along the internal network of tubules in a muscle fiber (the T system) despite muscle depolarization. These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue. |
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"Lame Acer" wrote
Science, Vol 305, Issue 5687, 1112-1113 , 20 August 2004 Enhanced: Lactic Acid--The Latest Performance-Enhancing Drug Yeah, I heard that on Morning Edition today: http://www.npr.org/features/feature.php?wfId=3861103 -Brendon |
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